| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 21/05/21 21.00 | UD Levante | FC Cadiz | 2:2 |
| 22/05/21 18.00 | Real Valladolid | Atletico Madrid | 1:2 |
| 22/05/21 18.00 | Real Madrid | FC Villarreal | 2:1 |
| 22/05/21 18.00 | SD Huesca | FC Valencia | 0:0 |
| 22/05/21 18.00 | CA Osasuna | Real Sociedad | 0:1 |
| 22/05/21 18.00 | Celta Vigo | Real Betis Siviglia | 2:3 |
| 22/05/21 18.00 | FC Elche | Athletic Bilbao | 2:0 |
| 22/05/21 18.00 | SD Eibar | FC Barcellona | 0:1 |
| 23/05/21 18.30 | FC Granada | FC Getafe | 0:0 |
| 23/05/21 21.00 | FC Siviglia | Deportivo Alaves | 1:0 |