| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 10/12/21 23.15 | CA Platense | CA Velez Sarsfield | 3:2 |
| 11/12/21 01.30 | Estudiantes de La Plata | CA Aldosivi | 2:3 |
| 11/12/21 21.00 | Argentinos Juniors | CA Sarmiento Junin | 2:0 |
| 11/12/21 21.00 | Union Santa Fe | Club Atlético Colón | 3:0 |
| 11/12/21 21.00 | Rosario Central | CA Huracan | 1:4 |
| 11/12/21 21.00 | Racing Club | CD Godoy Cruz | 2:1 |
| 11/12/21 21.00 | CA Patronato Parana | Gimnasia y Esgrima La Plata | 0:0 |
| 11/12/21 23.15 | Atletico Tucuman | River Plate | 1:1 |
| 12/12/21 02.00 | Boca Juniors | Central Cordoba | 8:1 |
| 12/12/21 21.00 | CA San Lorenzo | Newell's Old Boys | 3:2 |
| 12/12/21 23.15 | Defensa y Justicia Florencio Varela | CA Lanus | 2:1 |
| 13/12/21 01.30 | CA Talleres | Independiente | 1:2 |
| 14/12/21 00.00 | CA Banfield | Arsenal de Sarandi | 0:0 |