| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 07/10/22 02.15 | Denver Broncos | Indianapolis Colts | 9:12OT |
| 09/10/22 15.30 | Green Bay Packers | New York Giants | 22:27 |
| 09/10/22 19.00 | Buffalo Bills | Pittsburgh Steelers | 38:3 |
| 09/10/22 19.00 | Tampa Bay Buccaneers | Atlanta Falcons | 21:15 |
| 09/10/22 19.00 | Washington Commanders | Tennessee Titans | 17:21 |
| 09/10/22 19.00 | New Orleans Saints | Seattle Seahawks | 39:32 |
| 09/10/22 19.00 | New York Jets | Miami Dolphins | 40:17 |
| 09/10/22 19.00 | Cleveland Browns | Los Angeles Chargers | 28:30 |
| 09/10/22 19.00 | New England Patriots | Detroit Lions | 29:0 |
| 09/10/22 19.00 | Minnesota Vikings | Chicago Bears | 29:22 |
| 09/10/22 19.00 | Jacksonville Jaguars | Houston Texans | 6:13 |
| 09/10/22 22.05 | Carolina Panthers | San Francisco 49ers | 15:37 |
| 09/10/22 22.25 | Arizona Cardinals | Philadelphia Eagles | 17:20 |
| 09/10/22 22.25 | Los Angeles Rams | Dallas Cowboys | 10:22 |
| 10/10/22 02.20 | Baltimore Ravens | Cincinnati Bengals | 19:17 |
| 11/10/22 02.15 | Kansas City Chiefs | Las Vegas Raiders | 30:29 |