| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 23/09/22 02.15 | Cleveland Browns | Pittsburgh Steelers | 29:17 |
| 25/09/22 19.00 | Washington Commanders | Philadelphia Eagles | 8:24 |
| 25/09/22 19.00 | Tennessee Titans | Las Vegas Raiders | 24:22 |
| 25/09/22 19.00 | New England Patriots | Baltimore Ravens | 26:37 |
| 25/09/22 19.00 | New York Jets | Cincinnati Bengals | 12:27 |
| 25/09/22 19.00 | Carolina Panthers | New Orleans Saints | 22:14 |
| 25/09/22 19.00 | Minnesota Vikings | Detroit Lions | 28:24 |
| 25/09/22 19.00 | Miami Dolphins | Buffalo Bills | 21:19 |
| 25/09/22 19.00 | Indianapolis Colts | Kansas City Chiefs | 20:17 |
| 25/09/22 19.00 | Chicago Bears | Houston Texans | 23:20 |
| 25/09/22 22.05 | Los Angeles Chargers | Jacksonville Jaguars | 10:38 |
| 25/09/22 22.25 | Tampa Bay Buccaneers | Green Bay Packers | 12:14 |
| 25/09/22 22.25 | Seattle Seahawks | Atlanta Falcons | 23:27 |
| 25/09/22 22.25 | Arizona Cardinals | Los Angeles Rams | 12:20 |
| 26/09/22 02.20 | Denver Broncos | San Francisco 49ers | 11:10 |
| 27/09/22 02.15 | New York Giants | Dallas Cowboys | 16:23 |