| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 16/04/23 01.30 | Columbus Crew | New England Revolution | 1:1 |
| 16/04/23 01.30 | New York City FC | Nashville SC | 2:1 |
| 16/04/23 01.30 | New York Red Bulls | Houston Dynamo | 1:1 |
| 16/04/23 01.30 | Charlotte FC | Colorado Rapids | 2:2 |
| 16/04/23 01.30 | Toronto FC | Atlanta United FC | 2:2 |
| 16/04/23 01.30 | CF Montreal | D.C. United | 0:1 |
| 16/04/23 02.30 | FC Dallas | Real Salt Lake | 2:1 |
| 16/04/23 02.30 | Minnesota United FC | Orlando City | 1:2 |
| 16/04/23 02.30 | Chicago Fire | Philadelphia Union | 2:2 |
| 16/04/23 02.30 | St. Louis City SC | Cincinnati FC | 5:1 |
| 16/04/23 02.30 | Austin FC | Vancouver Whitecaps | 0:0 |
| 16/04/23 04.30 | San Jose Earthquakes | Sporting Kansas City | 3:0 |
| 16/04/23 04.30 | Portland Timbers | Seattle Sounders | 4:1 |
| 16/04/23 22.30 | Los Angeles Galaxy | Los Angeles FC | 2:3 |