| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 21/05/23 01.30 | Inter Miami CF | Orlando City | 1:3 |
| 21/05/23 01.30 | Philadelphia Union | New England Revolution | 3:0 |
| 21/05/23 01.30 | Cincinnati FC | Columbus Crew | 3:2 |
| 21/05/23 01.30 | D.C. United | Los Angeles Galaxy | 3:0 |
| 21/05/23 01.30 | Charlotte FC | Nashville SC | 1:2 |
| 21/05/23 01.30 | New York Red Bulls | CF Montreal | 2:1 |
| 21/05/23 02.30 | Chicago Fire | Atlanta United FC | 3:3 |
| 21/05/23 02.30 | FC Dallas | Houston Dynamo | 1:1 |
| 21/05/23 02.30 | Austin FC | Toronto FC | 1:0 |
| 21/05/23 03.30 | Colorado Rapids | Real Salt Lake | 2:3 |
| 21/05/23 03.30 | St. Louis City SC | Sporting Kansas City | 4:0 |
| 21/05/23 04.30 | Vancouver Whitecaps | Seattle Sounders | 2:0 |
| 21/05/23 04.30 | Los Angeles FC | San Jose Earthquakes | 2:1 |
| 21/05/23 04.30 | Portland Timbers | Minnesota United FC | 0:1 |