| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 25/10/25 02.25 | Inter Miami CF | Nashville SC | 3:1 |
| 26/10/25 22.30 | Philadelphia Union | Chicago Fire | 6:4d.c.r |
| 27/10/25 00.30 | Vancouver Whitecaps | FC Dallas | 3:0 |
| 27/10/25 02.30 | San Diego FC | Portland Timbers | 2:1 |
| 27/10/25 23.45 | Cincinnati FC | Columbus Crew | 1:0 |
| 28/10/25 02.00 | Minnesota United FC | Seattle Sounders | 3:2d.c.r |
| 28/10/25 23.45 | Charlotte FC | New York City FC | 0:1 |
| 30/10/25 03.30 | Los Angeles FC | Austin FC | 2:1 |
| 01/11/25 20.30 | New York City FC | Charlotte FC | 6:7d.c.r |
| 01/11/25 22.30 | Chicago Fire | Philadelphia Union | 0:3 |
| 02/11/25 00.30 | Nashville SC | Inter Miami CF | 2:1 |
| 02/11/25 02.30 | FC Dallas | Vancouver Whitecaps | 3:5d.c.r |
| 02/11/25 02.30 | Portland Timbers | San Diego FC | 5:4d.c.r |
| 03/11/25 00.30 | Columbus Crew | Cincinnati FC | 4:0 |
| 03/11/25 02.45 | Austin FC | Los Angeles FC | 1:4 |
| 04/11/25 04.45 | Seattle Sounders | Minnesota United FC | 4:2 |
| 08/11/25 01.00 | Charlotte FC | New York City FC | 1:3 |
| 08/11/25 22.00 | Minnesota United FC | Seattle Sounders | -:- |
| 09/11/25 00.00 | Cincinnati FC | Columbus Crew | -:- |
| 09/11/25 02.00 | Inter Miami CF | Nashville SC | -:- |
| 10/11/25 03.00 | San Diego FC | Portland Timbers | -:- |