| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 23/10/25 18.45 | KRC Genk | Real Betis Siviglia | 0:0 |
| 23/10/25 18.45 | FC Red Bull Salisburgo | Ferencvaros Budapest | 2:3 |
| 23/10/25 18.45 | Brann Bergen | Glasgow Rangers | 3:0 |
| 23/10/25 18.45 | Sporting Braga | Stella Rossa Belgrado | 2:0 |
| 23/10/25 18.45 | Olympique Lione | FC Basilea | 2:0 |
| 23/10/25 18.45 | Go Ahead Eagles Deventer | Aston Villa | 2:1 |
| 23/10/25 18.45 | FCSB Bukarest | Bologna | 1:2 |
| 23/10/25 18.45 | Fenerbahce Istanbul | VfB Stoccarda | 1:0 |
| 23/10/25 21.00 | Feyenoord Rotterdam | Panathinaikos Atene | 3:1 |
| 23/10/25 21.00 | Maccabi Tel Aviv | FC Midtjylland | 0:3 |
| 23/10/25 21.00 | OSC Lille | PAOK Salonicco | 3:4 |
| 23/10/25 21.00 | Celtic Glasgow | SK Sturm Graz | 2:1 |
| 23/10/25 21.00 | Malmö FF | Dinamo Zagabria | 1:1 |
| 23/10/25 21.00 | SC Friburgo | FC Utrecht | 2:0 |
| 23/10/25 21.00 | Nottingham Forest | FC Porto | 2:0 |
| 23/10/25 21.00 | Young Boys Berna | PFC Ludogorets Razgrad | 3:2 |
| 23/10/25 21.00 | Roma | Viktoria Pilsen | 1:2 |
| 23/10/25 21.00 | Celta Vigo | OGC Nizza | 2:1 |