| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 15/10/26 18.45 | NK Celje | Omonia Nicosia | 0:3 |
| 15/10/26 18.45 | Royale Union Saint-Gilloise | Real Sociedad | 1:1 |
| 15/10/26 18.45 | AZ Alkmaar | Hapoel Beer Sheva | 2:1 |
| 15/10/26 18.45 | Olympique Lione | Crystal Palace | 3:2 |
| 15/10/26 18.45 | Lech Poznan | Bayer 04 Leverkusen | 0:4 |
| 15/10/26 18.45 | FC Red Bull Salisburgo | Milan | 0:4 |
| 15/10/26 18.45 | SCU Torreense | AFC Sunderland | 1:2 |
| 15/10/26 18.45 | Sparta Praga | Lillestroem SK | 1:1 |
| 15/10/26 21.00 | Celta Vigo | Juventus | 1:2 |
| 15/10/26 21.00 | AFC Bournemouth | SK Sturm Graz | 3:0 |
| 15/10/26 21.00 | 1899 Hoffenheim | Besiktas Istanbul | 2:3 |
| 15/10/26 21.00 | Ferencvaros Budapest | Viktoria Pilsen | 2:1 |
| 15/10/26 21.00 | Olympique Marsiglia | Olympiacos Pireo | 0:1 |
| 15/10/26 21.00 | Dinamo Zagabria | RSC Anderlecht | 1:0 |
| 15/10/26 21.00 | Benfica Lisbona | Celtic Glasgow | 4:1 |
| 15/10/26 21.00 | Stade Rennes | OFI Crete | 2:1 |
| 15/10/26 21.00 | Jagiellonia Bialystok | FC Ararat-Armenia | 3:1 |
| 15/10/26 21.00 | NEC Nijmwegen | Levski Sofia | 1:1 |