| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 05/08/22 17.45 | Cagliari | AC Perugia | 3:2 |
| 05/08/22 18.00 | Udinese | AC Feralpi Salo | 2:1 |
| 05/08/22 21.00 | US Lecce | AS Cittadella | 2:3d.t.s |
| 05/08/22 21.15 | UC Sampdoria | Reggina 1914 | 1:0 |
| 06/08/22 17.45 | AC Pisa | Brescia | 1:4 |
| 06/08/22 18.00 | Spezia | Como | 5:1 |
| 06/08/22 21.00 | FC Empoli | SPAL Ferrara | 1:2d.t.s |
| 06/08/22 21.15 | FC Torino | Palermo FC | 3:0 |
| 07/08/22 17.45 | FC Venezia | Ascoli | 2:3 |
| 07/08/22 18.00 | Hellas Verona | SSC Bari | 1:4 |
| 07/08/22 21.00 | US Salernitana | Parma | 0:2 |
| 07/08/22 21.15 | AC Monza | Frosinone | 3:2 |
| 08/08/22 17.45 | Genoa | Benevento Calcio | 3:2 |
| 08/08/22 18.00 | Modena FC | Sassuolo | 3:2 |
| 08/08/22 21.00 | US Cremonese | Ternana | 3:2 |
| 08/08/22 21.15 | FC Bologna | Cosenza | 1:0 |