| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 12/12/24 14.00 | Vikingur Reykjavik | Djurgardens IF | 1:2 |
| 12/12/24 16.30 | FK Astana | FC Chelsea | 1:3 |
| 12/12/24 18.45 | Istanbul Basaksehir FK | 1. FC Heidenheim 1846 | 3:1 |
| 12/12/24 18.45 | Legia Varsavia | FC Lugano | 1:2 |
| 12/12/24 18.45 | HJK Helsinki | Molde FK | 2:2 |
| 12/12/24 18.45 | Olimpija Ljubljana | KSV Cercle Brügge | 1:4 |
| 12/12/24 18.45 | FC Petrocub Hincesti | Real Betis Siviglia | 0:1 |
| 12/12/24 18.45 | FC Noah | APOEL Nicosia | 1:3 |
| 12/12/24 18.45 | Dinamo Minsk | Larne FC | 2:0 |
| 12/12/24 18.45 | FC Copenhagen | Heart of Midlothian | 2:0 |
| 12/12/24 18.45 | Fiorentina | Linzer ASK | 7:0 |
| 12/12/24 21.00 | FC St.Gallen | Vitoria Guimaraes | 1:4 |
| 12/12/24 21.00 | FK Mlada Boleslav | Jagiellonia Bialystok | 1:0 |
| 12/12/24 21.00 | KAA Gent | TSC Backa Topola | 3:0 |
| 12/12/24 21.00 | Omonia Nicosia | SK Rapid Vienna | 3:1 |
| 12/12/24 21.00 | Pafos FC | NK Celje | 2:0 |
| 12/12/24 21.00 | Shamrock Rovers | FK Borac | 3:0 |
| 12/12/24 21.00 | The New Saints FC | Panathinaikos Atene | 0:2 |