| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 23/10/25 18.45 | AZ Alkmaar | SK Slovan Bratislava | 1:0 |
| 23/10/25 18.45 | Shakhtar Donezk | Legia Varsavia | 1:2 |
| 23/10/25 18.45 | Racing Club Strasburgo | Jagiellonia Bialystok | 1:1 |
| 23/10/25 18.45 | AEK Atene | FC Aberdeen | 6:0 |
| 23/10/25 18.45 | Breidablik Kopavogur | Kuopion PS | 0:0 |
| 23/10/25 18.45 | KF Shkendija | FC Shelbourne | 1:0 |
| 23/10/25 18.45 | BK Häcken | Rayo Vallecano | 2:2 |
| 23/10/25 18.45 | KF Drita Gjilan | Omonia Nicosia | 1:1 |
| 23/10/25 18.45 | SK Rapid Vienna | Fiorentina | 0:3 |
| 23/10/25 21.00 | Crystal Palace | AEK Larnaka | 0:1 |
| 23/10/25 21.00 | Shamrock Rovers | NK Celje | 0:2 |
| 23/10/25 21.00 | FSV Magonza 05 | HŠK Zrinjski Mostar | 1:0 |
| 23/10/25 21.00 | Lincoln Red Imps FC | Lech Poznan | 2:1 |
| 23/10/25 21.00 | Sigma Olomouc | KS Rakow Czestochowa | 1:1 |
| 23/10/25 21.00 | Samsunspor | Dynamo Kiev | 3:0 |
| 23/10/25 21.00 | Universitatea Craiova | FC Noah | 1:1 |
| 23/10/25 21.00 | Hamrun Spartans | FC Lausanne-Sport | 0:1 |
| 24/10/25 16.00 | HNK Rijeka | Sparta Praga | 1:0 |