| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 15/10/26 18.45 | KF Egnatia | FC Midtjylland | 1:1 |
| 15/10/26 18.45 | FC Lugano | Stella Rossa Belgrado | 3:2 |
| 15/10/26 18.45 | HNK Hajduk Split | Ajax Amsterdam | 2:1 |
| 15/10/26 18.45 | KAA Gent | Aarhus GF | 1:0 |
| 15/10/26 18.45 | Kuopion PS | Trabzonspor | 2:4 |
| 15/10/26 18.45 | Mjaellby AIF | Inter Escaldes | 2:0 |
| 15/10/26 18.45 | Panathinaikos Atene | FK Borac | 2:1 |
| 15/10/26 18.45 | ZSKA Sofia | AS Monaco | 1:2 |
| 15/10/26 18.45 | Riga FC | Kairat Almaty | 1:1 |
| 15/10/26 18.45 | Universitatea Craiova | FC Getafe | 1:1 |
| 15/10/26 21.00 | Atalanta | Pafos FC | 3:1 |
| 15/10/26 21.00 | Brighton and Hove Albion | FK Kauno Zalgiris | 4:0 |
| 15/10/26 21.00 | FC Copenhagen | Sporting Braga | 3:0 |
| 15/10/26 21.00 | FC Twente Enschede | FC Thun | 1:0 |
| 15/10/26 21.00 | Heart of Midlothian | FC Nordsjaelland | 1:1 |
| 15/10/26 21.00 | Sint-Truidense VV | FC Iberia 1999 | 2:0 |
| 15/10/26 21.00 | SC Friburgo | FK Jablonec | 3:2 |
| 15/10/26 21.00 | Brann Bergen | Lincoln Red Imps FC | 2:1 |