| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 16/09/25 18.45 | Athletic Bilbao | FC Arsenal | 0:2 |
| 16/09/25 18.45 | PSV Eindhoven | Royale Union Saint-Gilloise | 1:3 |
| 16/09/25 21.00 | Tottenham Hotspur | FC Villarreal | 1:0 |
| 16/09/25 21.00 | Benfica Lisbona | Qarabag | 2:3 |
| 16/09/25 21.00 | Juventus | Borussia Dortmund | 4:4 |
| 16/09/25 21.00 | Real Madrid | Olympique Marsiglia | 2:1 |
| 17/09/25 18.45 | Olympiacos Pireo | Pafos FC | -:- |
| 17/09/25 18.45 | Slavia Praga | FK Bodö/Glimt | -:- |
| 17/09/25 21.00 | Paris St. Germain | Atalanta | -:- |
| 17/09/25 21.00 | FC Liverpool | Atletico Madrid | -:- |
| 17/09/25 21.00 | Ajax Amsterdam | Inter | -:- |
| 17/09/25 21.00 | FC Bayern Monaco | FC Chelsea | -:- |
| 18/09/25 18.45 | Club Brügge | AS Monaco | -:- |
| 18/09/25 18.45 | FC Copenhagen | Bayer 04 Leverkusen | -:- |
| 18/09/25 21.00 | Sporting Lisbona | Qairat Almaty | -:- |
| 18/09/25 21.00 | Eintracht Francoforte | Galatasaray Istanbul | -:- |
| 18/09/25 21.00 | Manchester City | Napoli | -:- |
| 18/09/25 21.00 | Newcastle United | FC Barcellona | -:- |