| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 25/11/25 18.45 | Ajax Amsterdam | Benfica Lisbona | 0:2 |
| 25/11/25 18.45 | Galatasaray Istanbul | Royale Union Saint-Gilloise | 0:1 |
| 25/11/25 21.00 | FK Bodö/Glimt | Juventus | 2:3 |
| 25/11/25 21.00 | Borussia Dortmund | FC Villarreal | 4:0 |
| 25/11/25 21.00 | Napoli | Qarabag | 2:0 |
| 25/11/25 21.00 | Slavia Praga | Athletic Bilbao | 0:0 |
| 25/11/25 21.00 | Manchester City | Bayer 04 Leverkusen | 0:2 |
| 25/11/25 21.00 | Olympique Marsiglia | Newcastle United | 2:1 |
| 25/11/25 21.00 | FC Chelsea | FC Barcellona | 3:0 |
| 26/11/25 18.45 | Pafos FC | AS Monaco | 2:2 |
| 26/11/25 18.45 | FC Copenhagen | Kairat Almaty | 3:2 |
| 26/11/25 21.00 | FC Arsenal | FC Bayern Monaco | 3:1 |
| 26/11/25 21.00 | FC Liverpool | PSV Eindhoven | 1:4 |
| 26/11/25 21.00 | Sporting Lisbona | Club Brügge | 3:0 |
| 26/11/25 21.00 | Eintracht Francoforte | Atalanta | 0:3 |
| 26/11/25 21.00 | Paris St. Germain | Tottenham Hotspur | 5:3 |
| 26/11/25 21.00 | Atletico Madrid | Inter | 2:1 |
| 26/11/25 21.00 | Olympiacos Pireo | Real Madrid | 3:4 |